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Senior Director, AIRx Medicinal Chemistry (BOSTON)

Date Posted: Jun 27, 2026
Yearly: USD 212000.00 - USD 333190.00
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Job Detail

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    Location Cambridge, Massachusetts, United States of America
  • desktop_windows
    Job Type: Permanent
  • schedule
    Shift:
  • analytics
    Career Level:
  • group
    Positions:
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    Experience:
  • male
    Gender: No Preference
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    Degree:
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    Apply Before: Sep 25, 2026
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Job Description

Overview

The Senior Director, AIRx Medicinal Chemistry at Takeda Pharmaceutical will lead the AIRx initiative, focusing on AI-enhanced drug design and development. This role demands a deep understanding of medicinal chemistry and effective collaboration in a fast-paced, autonomous environment, with the goal of delivering innovative medicines to the clinic swiftly and efficiently.

Key responsibilities

  • Design and optimize drug candidates using deep SAR intuition and multi-parameter optimization.
  • Integrate AI/ML-generated design proposals with medicinal chemistry judgment, critically evaluating computational outputs.
  • Provide strategic oversight of CRO synthesis programs, defining compound lists and reviewing synthetic routes.
  • Interpret structural biology data to guide optimization efforts.
  • Stay current with competitive chemical matter and emerging chemistry approaches.
  • Contribute to AI/ML training datasets by ensuring standardized experimental data capture.

Required skills

  • PhD in medicinal chemistry or organic chemistry
  • 12-15+ years of drug discovery experience
  • Expertise in SAR-driven design and ADME optimization
  • Experience directing CRO-based chemistry programs
  • Knowledge of AI/ML design tools
  • Familiarity with structure-based drug design
  • Experience in therapeutic areas relevant to Takeda's research

What the company offers

  • Base salary range of $212,000.00 - $333,190.00
  • Eligible for short-term and long-term incentives
  • Medical, dental, and vision insurance
  • 401(k) plan with company match
  • Short-term and long-term disability coverage
  • Tuition reimbursement program
  • Paid volunteer time off
  • Up to 80 hours of sick time per year
  • Up to 120 hours of paid vacation for new hires

Skills Required

Company Overview

Takeda Pharmaceutical
Cambridge, Massachusetts, United States of America
24 Current Jobs Openings

Takeda Pharmaceutical is a global biopharmaceutical company committed to bringing better health and a brighter future to people worldwide. We focus on developing innovative medicines based on profound science and patients' needs, actively engaging in... Read More

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