Overview In this role you will lead the design, production, and quality control of research-grade RNA for LNP discovery and development, serving as the technical lead for RNA manufacturing and analytics. You will develop robust workflows for diverse RNA formats and collaborate across formulation, analytical, and biology teams to optimize delivery and activity. You will troubleshoot complex issues, interpret quality data, and drive process improvements with a hands-on, problem-solving approach. This position offers the chance to shape RNA-LNP programs in cancer therapies and contribute to scalable, transfer-ready workflows. Compensation / Benefitsmedical, dental, vision, and life insurance plansdiscretionary annual bonusdiscretionary stock-based long-term incentivespaid time offbenefits packagesalary range provided ResponsibilitiesOwn end-to-end RNA production at research scale (DNA template prep, in vitro transcription, capping, polyadenylation or encoded poly(A) strategies, purification, concentration, buffer exchange, sterile handling, storage)Develop, optimize, and standardize workflows for linear mRNA and expand to circular RNA, self-amplifying RNA, and other formatsDesign and evaluate RNA sequence and chemistry variables (UTRs, coding sequence optimization, poly(A), cap structures, modified nucleotides) to improve expression, stability, and tolerabilityEstablish fit-for-purpose RNA QC methods and acceptance criteria (identity, concentration, purity, integrity, size, capping, poly(A), residual DNA, dsRNA, endotoxin, bioburden, activity)Operate, maintain, qualify, and troubleshoot RNA production/analysis instruments (liquid handlers, chromatography, TFF, capillary electrophoresis, HPLC, spectrophotometry, fluorometry, qPCR/dPCR)Collaborate with LNP formulation scientists to define RNA input specs and assess compatibility with formulation and encapsulationDevelop data packages and documentation enabling comparability across lots, constructs, and formulationsLead investigations of failed/variable RNA and LNP experiments with root-cause analysis and corrective actionsHypothesize, design experiments, and interpret results to guide platform and program decisionsCollaborate with molecular/cell biologists, formulation, analytics, automation, and in vivo teams to advance RNA-LNP programs for cancer therapiesMaintain rigorous records, inventories, and safe lab practices; contribute to scalable workflowsMentor junior scientists as a technical resource for RNA design, manufacturing, analytics, and troubleshooting Key requirementsDoctorate in Molecular Biology, Biochemistry, Chemical Biology, Bioengineering, Pharmaceutical Sciences, RNA Biology, or related fieldOR Master's degree with 4+ years relevant experienceOR Bachelor's degree with 6+ years relevant experiencePreferred: 3+ years in industry/postdoc with RNA payloads in LNP formulation or nucleic acid deliverystrong communicationcollaborationproblem-solvingRNA production and purification workflowsRNA sequence and chemistry design (UTRs, coding sequence, cap structures, poly(A), modified nucleotides)RF and QC methods for RNA (identity, concentration, purity, integrity)
Not specified in the original listing.
Not specified in the original listing.
