Overview In this role you will establish and advance RNA production and analytics capabilities for LNP discovery programs, bridging design, manufacturing, and quality control. You will lead hands-on RNA workflows and ensure high-quality RNA for formulation and biological evaluation across multiple programs. You'll work with cross-functional teams to optimize RNA formats and translate data into actionable decisions. This position offers impact in advancing RNA-LNP platforms for cancer therapies and shaping program strategies. Compensation / Benefitsdiscretionary annual bonusdiscretionary stock-based long-term incentivespaid time offmedical insurancedental insurancevision insurance ResponsibilitiesOwn end-to-end research-scale RNA production including DNA template prep, in vitro transcription, capping, polyadenylation, purification, concentration, buffer exchange, sterile handling, and storageDevelop and standardize workflows for linear mRNA; expand to circular RNA, self-amplifying RNA, and other emerging formatsDesign and evaluate RNA sequence and chemistry variables to improve expression, stability, and tolerabilityEstablish fit-for-purpose RNA quality-control methods and acceptance criteria for identity, concentration, purity, integrity, size, capping, poly(A), residual DNA, dsRNA, endotoxin, bioburden, and functional activityOperate and troubleshoot RNA production/analytical instruments (liquid handling systems, chromatography/TFF, capillary electrophoresis, HPLC, spectrophotometry, fluorometric assays, qPCR/dPCR)Collaborate with LNP formulation scientists to define RNA input specs, assess formulation compatibility, and determine encapsulation impact on activityDevelop data packages to enable comparability across RNA lots and constructsLead investigations of failed or variable RNA/LNP experiments and implement corrective actionsGenerate hypotheses, design experiments, analyze data, and recommend next steps for platform/program teamsCollaborate with molecular/cell biologists, formulation scientists, analytical scientists, automation experts, and in vivo teams to advance RNA-LNP programsMaintain rigorous records, inventories, and safe lab practices; contribute to scalable workflowsMentor junior scientists and serve as a technical resource for RNA design, manufacturing, analytics, and troubleshooting Key requirementsPhD in relevant field OR MSc with 4+ years of experience OR BSc with 6+ years of experienceDemonstrated RNA payload expertise in LNP formulation, encapsulation, or nucleic acid delivery platformsDeep expertise in RNA design, nucleotide chemistry, purification, analytical methods, and release criteriaExperience in RNA production workflows and QC methods; familiarity with regulatory-compliant documentationAbility to interpret multidimensional quality data and translate into decisionsStrong collaboration and communication skills; ability to lead cross-functional teamsExperience with cell therapy, in vivo studies, or oncology research programs (preferred)strong communicationcollaborationproblem-solvingin vitro transcription, RNA capping, polyadenylation strategieslinear, circular, and self-amplifying RNA formatsRNA sequence design and chemistry (UTRs, coding sequence optimization, cap structures, modified nucleotides)
Not specified in the original listing.
Not specified in the original listing.
