Overview In this Senior Scientist role, you will lead scale-up of cell culture bioprocesses from bench to pilot (200L-2000L) within the Genomic Medicine Cell Therapy Development Group in Waltham. You will act as a technical SME, driving process understanding, robustness, and cross-functional alignment with downstream and manufacturing teams. Your work translates lab findings into scalable manufacturing processes that support an immunotherapy-focused pipeline. This is a hands-on, impact-oriented position at the intersection of science and engineering with a strong leadership dimension. Compensation / Benefitshealth and wellbeing benefits14 weeks' gender-neutral parental leavegrowth opportunities and career developmentcompetitive rewards packagepromotion or lateral move opportunitiesglobal/interactive collaboration opportunities ResponsibilitiesLead scale-up activities from bench scale to pilot (200L-2000L) using engineering principles to ensure large-scale comparabilityCollaborate with process development scientists to translate lab findings into scalable manufacturing processesReview and approve JSAs written by equipment owners and provide feedbackTrain employees on best practices for safety, efficiency, and operationsBuild robust interfaces with the CMC community and promote adoption of best practicesDemonstrate expertise in upstream process operations across scalesLead RCA investigations for process deviations and equipment failures at pilot scalePresent findings to senior management and external stakeholders at conferences Key requirementsMaster's degree in Chemical Engineering, or related discipline with minimum 6 years in large-scale bioreactors, or Ph.D with minimum 4 years in industry related to large-scale bioreactorsStrong background in cell culture bioreactor operations and scale-up technologiesBiotech/pharma industry experience in a cell culture role with strong operational excellenceExperience with perfusion process operations at various scalesUnderstanding of engineering principles related to cell culture processesAbility to lead matrix teams for operations and lab managementleadership and mentorshipcross-functional collaborationeffective communicationupstream bioprocessingcell culture bioreactor operationsscale-up from bench to 2000L
Not specified in the original listing.
Not specified in the original listing.
